Hemoglobin subunit gamma-2 (HBG2) (38) was reported in association with high-altitude pulmonary hypertension (HAPH), while RNA-binding protein with multiple splicing 2 (RBPMS2) (39) was identified as a potential biomarker and therapeutic target in idiopathic pulmonary arterial hypertension. This evidence concerns the gene HBG2 and idiopathic pulmonary arterial hypertension.