The work presented here used longitudinal Elevated Plus Maze (EPM) testing in male and female wild type rats and in male and female rats with knockout of the PTEN-induced putative kinase 1 gene (Pink1–/–) to determine whether these are suitable models for translational studies examining the neural substrates that underpin the sex-specific expression of anxiety symptoms in PD. This evidence concerns the gene PINK1 and Parkinson disease.