Unlike a surprising number of other rodent models of PD that fail to emulate clinically observed anxiety and/or male/female differences in these signs, the data presented here identify Pink1–/– rats as strongly suited to lead translational efforts to better understand the neurobiological and neuroendocrine bases for anxiety symptoms in PD, their sex differences and their sex-specific sensitivities to therapeutic interventions. The gene discussed is PINK1; the disease is Parkinson disease.