Further, with data in hand showing that Pink1–/– rats sex-specifically model motor, cognitive and affective complications of PD, this strain may offer an especially powerful platform for learning more about the predictive powers and interactions among major PD symptom clusters, and for making therapeutic advances that avoid common complications of treatments that benefit motor function exacerbating non-motor deficits and vice versa (Rektorova, 2019). This evidence concerns the gene PINK1 and Parkinson disease.