However, further evaluation is required to determine if treatment through apical delivery and in vivo can rescue this level of coordinated ciliary activity to produce effective MCC, where some promising results have been shown with aerosolized delivery of SORT-LNP-DNAI1 mRNA to human bronchial epithelial cells and nonhuman primates (Hennig et al., 2025). Here, DNAI1 is linked to Merkel cell skin cancer.