For example, treatment of Dnai1flox/flox/CreER+ mice with different doses of tamoxifen showed that the rate of MCC was correlated with the level of intact genomic Dnai1, where animals with at least 20% of normal Dnai1 levels exhibited MCC with no mucus accumulation and no sinusitis phenotype (Ostrowski et al., 2014). The gene discussed is DNAI1; the disease is Merkel cell skin cancer.