Overall, we found that BrB is elevated in MG upon phagocytosis of RBC, which could activate AhR and upregulate expression of Mrp1 and LGN, contributing to MG’ self-protection for more efficient phagocytosis function; and the AhR agonists could promote hematoma resolution and benefit post-ICH recovery in an animal model of ICH. The gene discussed is GPSM2; the disease is hematoma.