Whilefigures vary, approximately 10–30% of oral immunotherapypatients drop out due to adverse effects, among other reasons.−,  Ana o 3 cognate soluble IgE has emerged as a strong predictor ofclinically relevant allergy, but cashew nuts contain three major allergens(including Ana o 1 and Ana o 2), and a majority of patients are sensitiveto all three. Multiallergen IgE profilesare common, and this can complicate desensitization strategies becausetargeting a single allergen may not fully address the immunologicsensitivities of an individual. This evidence concerns the gene IGHE and allergic disease.