APOE and Hepatic fibrosis: While we demonstrated that Apoe KO mice are more susceptible to alcohol-induced injury and fibrosis, we did not generate macrophage-specific Apoe KO mice to directly assess the role of macrophage-derived Apoe. Given that a previous study revealed a critical role for macrophage Apoe in the resolution of lung fibrosis [22], we hypothesize that APOE+ macrophages may similarly promote the resolution of liver fibrosis in alcohol-induced liver injury.