The genetic cause of hypophosphatasia (HPP) has been causatively linked to loss-of-function mutations in the ALPL gene (HGNC ID:438)8–10, which encodes the ectoenzyme ’Tissue Nonspecific Alkaline Phosphatase’ (TNAP; UniProt ID: P05186). The gene discussed is ALPL; the disease is hypophosphatasia.