In the SJNB14 model, the expression of SOX11 was reduced after the tumors switched their cell state from ADRN to other cell states, such as melanoma-like, which conversely expressed high levels of MITF. One study showed that SMARCE1 promoted neuroblastoma tumorigenesis through assisting MYCN-mediated transcriptional activation96. The gene discussed is SMARCE1; the disease is neuroblastoma.