While indisulam may be important to stimulate the activity of CD8 T cells to boost the efficacy of ICBs by producing neoantigens through alternating pre-mRNA splicing105, our study demonstrated that NK cells might be more critical for eliminating cancer cells in our syngeneic C-MYC and transgenic TH-MYCN/ALKF1178L neuroblastoma models. Here, MYCN is linked to neuroblastoma.