RAG2 and neuroblastoma: To test this hypothesis, we implanted syngeneic C-MYC–driven neuroblastoma (derived from Dbh-iCre/CAG-C-MYC mouse30) into immune competent C57BL/6 mice, Rag2-/- mice (no T and B cells, intact NK cells), and immune deficient NSG mice without T, B, and NK cells (Fig. 7a), which were then treated with indisulam at the indicated schedules.