Consistent with the RNA-seq results, the indisulam-resistant tumor cells showed a significant enrichment of H3K27Ac at gene loci of MES transcriptional factors (i.e., SMAD3, TEAD4, MYC, Fig. 2j; Supplementary Fig. 4d), mesenchymal genes such as those involved in muscle contraction, HIPPO (YAP/TAZ) signaling pathway, and interferon alpha and beta signaling (Supplementary Fig. 4b). Here, SMAD3 is linked to neoplasm.