The tumor cell fraction (Mycn+) was decreased from 96.45% (control) to 51.01% (indisulam), while the mesenchyme-like cell fraction (Prrx1+) was increased from 0.80% to 4.23%, and the Schwann-like cell fraction was increased from 0.29% to 4.26% (Fig. 8b; Supplementary Fig. 8, Supplementary data 8). Here, PRRX1 is linked to neoplasm.