We investigated glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), ghrelin, and motilin influences on gastric motility and appetite, to compare healthy individuals and people with obesity.<h4>Methods</h4>Subjects (healthy n = 41; obesity n = 32) consumed a 270-kcal meal and a wireless motility capsule. The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.