Thepleiotropic effects of IL-6 in the inflammatory-related immune effect includestimulating the production of acute phase proteins (C-reactive protein, fibrinogen),as well as inhibiting the synthesis of albumin, fibronectin, andtransferrin[28].Additional proof as a bridge linking IL-6 and kidney disease is that eGFR isinversely associated with circulating stages of pro-inflammatorybiomarkers[29]. Here, FN1 is linked to kidney disorder.