We first tested whether known SETD2 mutations altered cell death by ferroptosis in ccRCC, using A498 cells, which are SETD2 deficient due to loss of one allele on the short arm of chromosome 3 (3p) and a frameshift mutation in the second allele (A498 SETD2−/−), and 786-O ccRCCs, which encode a functional SETD2 (Fig. 6C). The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.