To assess whether caspase-dependent cell death was responsible for spontaneous lipodystrophy in HoipA-KO mice, we codeleted caspase-8 in mature adipocytes by crossing Casp8A-KO with HoipA-KO mice (hereafter Casp8A-KOHoipA-KO), and since deletion of caspase-8 inactivation may unleash necroptosis in mouse cells, we additionally deleted MLKL and evaluated them under NCD. This evidence concerns the gene CASP8 and lipodystrophy.