ZEB1 and cancer: It was shown the TCF4/ β-catenin complex binds to the promoter of ZEB1 and activates its expression [60]; in cancer TCF4 and ZEB1 reciprocally modulate each other’s transcriptional activity: ZEB1 enhances TCF4/β-catenin-mediated transcription and Wnt signaling switches ZEB1 from a repressor into an activator [61].