Previous studies have shown that silencing PROK1 exerts its anti-pancreatic cancer effects by inhibiting the PI3K/AKT/mTOR pathway, leading to increased levels of Bax and Cleaved Caspase 3, and decreased levels of PCNA and Bcl-2 in pancreatic cancer cells [53]. The gene discussed is BAX; the disease is familial pancreatic carcinoma.