FOXO3 and central nervous system cancer: For example, in breast cancer, TRIM6 promotes tumor progression by facilitating the degradation of STUB1, thereby enhancing cancer cell proliferation and migration [29]; in colorectal cancer, TRIM6 promotes tumor cell proliferation through regulation of the TIS21/FoxM1 axis [30]; while in glioma, TRIM6 drives malignant progression by promoting the ubiquitination and degradation of FOXO3A [31].