AKT1 and acute myeloid leukemia: These findings are consistent with the present study, where TRIM6 overexpression increased Bax and Cleaved Caspase 3 protein levels in AML cells, while Bcl-2, PCNA, c-Myc, P-PI3K, and P-AKT protein levels were significantly reduced, as shown by Western blot analysis.However, in vivo experiments have not yet been conducted to further validate these findings.