These findings are consistent with the present study, where TRIM6 overexpression increased Bax and Cleaved Caspase 3 protein levels in AML cells, while Bcl-2, PCNA, c-Myc, P-PI3K, and P-AKT protein levels were significantly reduced, as shown by Western blot analysis.However, in vivo experiments have not yet been conducted to further validate these findings. This evidence concerns the gene PCNA and acute myeloid leukemia.