Upregulation of DDLPS MDM2 by GP130 signal transduction may be facilitated by STAT1 and STAT3 transcription factors, as seen in colorectal cancer [37] where GP130 activation by IL6 cytokine family member leukemia inhibitory factor led to increased MDM2 levels in a STAT3-dependent fashion [37]. Here, LIF is linked to colorectal cancer.