Notably, certain SOCs were linked to significant ADEs not previously documented in the drug inserts, including “congenital, familial and genetic disorders” (n = 160, ROR 1.88, PRR 1.87, IC 0.9, EBGM 1.87), “ear and labyrinth disorders” (n = 141, ROR 1.18, PRR 1.18, IC 0.24, EBGM 1.18), and “pregnancy, puerperium, and perinatal conditions” (n = 86, ROR 0.72, PRR 0.72, IC −0.47, EBGM 0.72) (Table 4). This evidence concerns the gene CISH and hereditary disease.