Fibrosis‐related genes such as Col8a1,[64]Lgr5 (scleroderma‐related)[65] were upregulated, along with Ccn5 (anti‐fibrotic[66]), Loxl (collagen crosslinking[67]), Eln (elastic fiber synthesis[68]) and Cdkn1c (proliferation inhibitor[69]) were upregulated; while dermal regeneration‐associated gene Trps1[70] was downregulated (Figure 3D). The gene discussed is COL8A1; the disease is scleroderma.