Indeed, these two variants, P229S and L353F, share a lot in common: 1) both mutations are situated in the talin-1 head F2F3 domains; 2) cells bearing these mutations show defects in cell migration and integrin activation; 3) both patients are suffering from thrombocytopenia, leukopenia, congenital cataract, and recurring episodes of bronchitis. The gene discussed is TLN1; the disease is Thrombocytopenia.