,23,24 Moreover, the increasing levels of anti-PLA1 IgG antibodies in the chronic phase of infection for both strains suggests that these antibodies may contribute to host control of parasitaemia since we already demonstrated that the presence of anti-TcPLA1 antibodies in the sera of T. cruzi infected mice with RA, K98, and CvD strains, have shown to modulate TcPLA1 activity and inhibit the invasion of non-phagocytic cells.22 Here, POU2F3 is linked to infection.