CEACAM5 and colorectal carcinoma: Second, CEA interoperates with the hnRNP M4 on the surface of Kupffer cells, inducing the release of inflammatory mediators such as IL-1β and TNF-α (7), upregulating the expression of endothelial adhesion molecules in hepatic sinusoids, and accelerating CRC cell-specific anchoring and liver micro-environment colonization.