Under hypoxia and acidosis conditions, MCs release pro-angiogenic mediators such as VEGF-A/VEGF-A/CXCL8/endothelin-1 and VEGF-C/D pro-lymphangiogenic factors (37, –, 39) to rebuild the tumor vasculature network and accelerate the metastatic progression, which may be associated with stem cell factors (SCF). This evidence concerns the gene EDN1 and neoplasm.