To further evaluate the direct contribution of MAA‐targeting IgM antibodies to ethanol‐induced liver disease in mice, MDA‐ and MAA‐specific IgM (LR04; 200 μg) or isotype control IgM was administered twice to female wildtype mice via tail vein injection during the chronic‐binge ethanol feeding model; at the start of ethanol feeding and 5 days later (Figure 5A). This evidence concerns the gene CD40LG and liver disorder.