Malrotation can be caused by alteration in left-right asymmetry pathways and indeed Hand1Hand2/Hand2 Visium and RNAscope expression analysis reveals changes in Wnt5a and Pitx2 expression, which are known causes of omphalocele (Sanketi et al., 2022; Welsh et al., 2013) (Figs 5 and 6). The gene discussed is WNT5A; the disease is omphalocele.