The clinical features of LAMA2-MD can be divided into two subgroups: (1) severe, early-onset LAMA2-related congenital muscular dystrophy (LAMA2-CMD, OMIM 607855), and (2) mild, late-onset autosomal recessive limb-girdle muscular dystrophy-23 (LGMDR23, OMIM 618138) (Tan et al., 2021). Here, LAMA2 is linked to Menkes disease.