LAMA2 and Menkes disease: Recently, cortical malformations, including polymicrogyria, lissencephaly-pachygyria, and cobblestone, most severe in the occipital lobe, such as occipital pachygyria, have been thought to be an important manifestation of the brain pathology in LAMA2-MD (Jayakody et al., 2020; Camelo et al., 2023).