Since the initial identification of the merosin-deficient families with LAMA2 homozygous mutations in 1995 (Helbling-Leclerc et al., 1995), LAMA2-CMD has been the most common CMD subtype worldwide (Sframeli et al., 2017; Abdel Aleem et al., 2020; Ge et al., 2019). Here, LAMA2 is linked to congenital muscular dystrophy.