PSEN1 and Alzheimer disease: Our results revealed a significant reduction in LC3‐II levels in untreated APP/PS1 mice (AD, light red bar) compared to CaAKG treated APP/PS1 slices (AD/CaAKG, dark red bar) (p = 0.0152, U‐test, n = 5), indicating impaired autophagic activity in the APP/PS1 mice and that CaAKG increases autophagy (Figure 6A,B).