Interferon-gamma (IFN-γ) primarily recognized for its pro-inflammatory properties and its role in anti-tumour immunity, has also been shown to influence muscle regeneration.27 IFN-γ promotes myoblast proliferation but inhibits myogenic differentiation in vitro, as indicated by reduced myosin heavy chain content.28 This suggests that dysregulated IFN-γ expression can not only enhance the inflammatory response but also impair muscle regeneration.29 This evidence concerns the gene IFNG and neoplasm.