Among the most frequently reported cancer-associated SNPs are HIF1A rs11549465, rs11549467, and rs2057482.23 Additionally, studies have found that HIF1A SNPs are associated with worse disease prognosis of cancer patients and an increased risk of metastasis.23,27,28 Most studies conducted to date have focused on the association of HIF-1A with cancer risk, but only a few investigated treatment response and survival. Here, HIF1A is linked to cancer.