A study examining the association of HIF1A polymorphisms with prognosis in patients with advanced NSCLC treated with radiotherapy found that rs2057482 CT or TT genotypes carriers had shorter PFS and worse OS compared to the CC genotype carriers.32 On the other hand, in patients with early-stage (TNM I/II) NSCLC undergoing surgical treatment, the CT and TT genotypes seemed to have a protective effect on OS and DFS compared to the CC genotype. Here, HIF1A is linked to non-small cell lung carcinoma.