CDH2 and neoplasm: These results may be due to the high biological variability within bladder tumours, caused by various factors such as intratumoural heterogeneity and different molecular subtypes.32–34 The high expression of both E- and N-cadherin in pT1 and pT2 HG cancer tissue may reflect the complex and transitional nature of epithelial-to-mesenchymal transition (EMT) and its reversal, mesenchymal-to-epithelial transition (MET), in tumour progression.