Our observations align with previous reports in the literature, which show that downregulation of FAK using antisense oligonucleotides results in enhanced apoptosis in melanoma cell lines.53 While apoptosis has previously been linked to FAK downregulation or inhibition, the induction of necrosis following FAK downregulation represents a novel finding.50 In T24 cells, FAK downregulation was most pronounced with p45, followed by p46 and p44. Here, PTK2 is linked to melanoma.