Specifically, we observed the highest expression levels of E-cadherin and N-cadherin in pT1 HG and pT2 HG bladder cancer tissues, while the expression levels of FAK and p-FAK remained consistent across different grades and stages of bladder cancer tissue and were higher than in normal bladder tissue (Figures 2A, B and Supplementary Figure 1). Here, PTK2 is linked to urinary bladder carcinoma.