PTK2 and urinary bladder cancer: In this study, we aimed to investigate the role of FAK in ex vivo and in vitro models of bladder cancer, focusing particularly on the effects of FAK inhibition on normal urothelial cells compared to urothelial cancer cells, as most bladder cancers originate from the urothelium.5 We conducted molecular characterisation of several focal adhesion and adherens junctional proteins in ex vivo human bladder tissues and in different in vitro models.