The intravenous injection of LNPs (136.83 nm, 1:1 ratio of TAT and cRGD) encapsulating the Insig1/2 loop 1 peptide (LNP@Insig1/2 loop 1 peptide) or LNPs with a scramble peptide (LNP@scramble) into mice revealed that the LNPs with a scramble peptide had no obvious effect on tumor growth (Figure 3a–c). Here, INSIG1 is linked to neoplasm.