INSIG1 and metabolic dysfunction-associated steatohepatitis: Notably, in line with a previous report showing that a high‐fat diet activates AKT and promotes metabolic dysfunction‐associated steatohepatitis (MASH) and liver tumorigenesis,[27] the high‐fat diet enhanced Insig1 S207 and Insig2 S151 phosphorylation (Figure 5f).