Of note, semaglutide significantly reduced circulating low‐density lipoprotein cholesterol (LDL‐C) (Figure S5a, Supporting Information) and high‐density lipoprotein cholesterol (HDL‐C) levels (Figure S5b, Supporting Information), while it had no significant effect on AKT‐mediated Insig1 S207 phosphorylation (Figure S5d, Supporting Information) or lipid uptake (Figure S5c, Supporting Information) in cultured HCC cells. The gene discussed is INSIG1; the disease is hepatocellular carcinoma.