Supporting this role, Handschin et al. (116), showed that mice lacking PGC-1α in skeletal muscle exhibited elevated circulating IL-6 and impaired glucose regulation, while Pérez et al. (117), demonstrated that PGC-1α deficiency in the pancreas amplified NF-κB-mediated IL-6 expression and worsened inflammation during pancreatitis. Here, IL6 is linked to pancreatitis.