This cross-sectional study included 25 women with COPD-BS and 25 women with COPD-TS, and the relationship with SAD was assessed by impulse oscillometry (IOS), alongside measurements of interleukins (IL-1ra, IL-2, IL-4, IL-8, IL-9, IL-13, and IL-17) and eotaxin using the multiplex test (Bio-Plex), in addition to eosinophils total blood. Here, IL4 is linked to chronic obstructive pulmonary disease.