The results showed the following: (1) The oxy-Hb activation of the left DLPFC for the groups with depression-high resilience and healthy-low resilience was significantly higher under the positive emotional valence condition than under the negative emotional valence condition, while the oxy-Hb activation in the left DLPFC was not significantly different between the two emotional valence conditions for the groups with depression-low resilience and healthy-high resilience. The gene discussed is GSTM1; the disease is depressive symptom measurement.