Other significant factors influencing 30-day mortality included the presence of atrial fibrillation, pneumonia, CKD, and use of ACE inhibitors/ARBs, beta-blockers, furosemide, mechanical ventilation, as well as age, weight, platelet count (PLT), prothrombin time (PT), PaO2, and Charlson score (all p < 0.05). The gene discussed is ACE; the disease is chronic kidney disease.