In this context, this study aims to evaluate the combined prognostic potential of three biomarkers, each reflecting a key facet in sepsis pathophysiology: coagulation (prothrombin time-international normalized ratio (PT-INR)), inflammation (interleukin-6 (IL-6)), and immunometabolism (high-density lipoprotein (HDL)). The gene discussed is IL6; the disease is Sepsis.