Minbo Yan et al. observed that when NR3C1 expression was silenced in renal cancer cells, lipid metabolism disorder, endoplasmic reticulum stress, and expression of mitotic genes were significantly enriched, which may be achieved through the ATF6-PINK1/BNIP3 pathway (Yan et al., 2023). Here, NR3C1 is linked to renal carcinoma.