Shumail Syed et al. identified two intronic variants (rs10482672 and rs11749561) within the NR3C1 gene that are linked to PCOS risk by regulating the stress response, marking the first study to designate NR3C1 as a risk gene for PCOS (Syed and Gragnoli, 2024). Here, NR3C1 is linked to polycystic ovary syndrome.