It has been demonstrated that abnormal expression of NR3C1 in various malignant tumors, including colon cancer, renal clear cell carcinoma, breast cancer, and pancreatic cancer, affects the proliferation and migration of cancer cells (Zhai et al., 2024; Yan et al., 2023; Dwyer et al., 2023; Wang et al., 2023), although the number of related studies remains relatively limited. This evidence concerns the gene NR3C1 and colonic neoplasm.