Amy R. Dwyer et al.'s research shows that cell damage, stress, and related factors in the tumor microenvironment can activate MAPK, causing phosphorylation of the glucocorticoid receptor at Ser134, which regulates the migration-related (NEDD9, CSF1, RUNX3) and metabolism-related (PDK4, PKG1, PFKFB4) gene sets to regulate the development and progression of triple-negative breast cancer. Here, PDK4 is linked to triple-negative breast carcinoma.