HSPA13 and Dravet syndrome: Although the role of miRNAs in gene expression regulation through nuclear and cytoplasmic mechanisms is well established40,41, in the present study, owing to the in silico design, it was not possible to evaluate the regulatory mechanisms of miRNAs with HSPA13. In addition to methodological limitations, we need to overcome the challenges of reproducing conditions closer to those observed in DS, as there are extra copies of genes and a lack of knowledge regarding the impacts of this genetic imbalance on miRNA-target regulatory mechanisms.