It has been confirmed in clinical practice to predict the prognosis of ovarian cancer 25, hepatocellular carcinoma 25, 26, breast cancer 19, and esophageal cancer 27, etc. However, the mechanisms underlying HALP have not been fully elucidated, and the physiological and pathological roles of these peripheral blood parameters may explain this to some extent. This evidence concerns the gene NAT10 and esophageal cancer.