POLE and endometrial cancer: The Cancer Genome Atlas (TCGA) molecular classification of endometrial cancer integrates genomic, transcriptomic, proteomic, gene copy number, and methylation data, categorizing endometrial cancer into four subtypes: POLE ultra-mutated (POLE-mut), microsatellite instability-high (MSI-H), copy number low (CN-L), and copy number high (CN-H) 8.