PCK1 and colorectal carcinoma: IHC data from the HPA database provided robust support for the differential expression patterns of 9 hypoxia-related DEGs (BGN, CA12, MIF, MT1E, NEDD4L, PCK1, SELENBP1, SLC2A1, and TGFBI) in CRC patients, consistent with observations at both mRNA and protein levels (Figure 2).