IHC data from the HPA database provided robust support for the differential expression patterns of 9 hypoxia-related DEGs (BGN, CA12, MIF, MT1E, NEDD4L, PCK1, SELENBP1, SLC2A1, and TGFBI) in CRC patients, consistent with observations at both mRNA and protein levels (Figure 2). The gene discussed is NEDD4L; the disease is colorectal carcinoma.