Meanwhile, the N-terminal of FBN1 is also the most common site in patients with normal heart type, with more than 70% of normal patients having N-terminal mutations of FBN1.Mutations in the middle region were found to have the highest risk, with 60% of patients having organic heart disease, and mutations in the neonatal region (exons 24-32), a region clinically associated with high-risk Marfan 48, were found to have organic heart disease in more than 90% of patients. Here, FBN1 is linked to heart disorder.