To realize the role of miR-548aj-3p and miR-3127-3p in OA and RA, we predicted miR-548aj-3p and miR-3127-3p binding sites target the 3' untranslated regions (3'UTRs) of IL-1β, IL-6, and MMP-13. This evidence concerns the gene MMP13 and rheumatoid arthritis.