Shen et al. reported that the natural compound thonningianin A activated L-type calcium channels to induce autophagy, downregulating RUNX2/BMP2 expression, and validated its synergistic effects via Cav1.2 α1C targeting in type 2 diabetes mellitus (T2DM) models (95). This evidence concerns the gene BMP2 and type 2 diabetes mellitus.