SREBF1 and metabolic dysfunction-associated steatotic liver disease: Several other mechanisms for the anti-NAFLD activity of QHF are also discussed, including the upregulation of peroxisomal proliferator-activated receptor α (PPARα), regulation of adipocytokine release, the suppression of insulin signaling, the downregulation of Sterol Regulatory Element Binding Protein-1c (SREBP-1c) levels, the suppression of systemic and macrophage inflammation, and the modulation of the gut microbiome 115 In China, for several years, Fufang-Zhenzhu-Tiao Zhi Capsule (FTZ), a cocktail of eight Chinese medical herbs, improved NAFLD in mice by altering the gut microbiota.