In HCC, Luo et al. (2013) showed that caudatin treatment dramatically decreased invasive potential through downregulation of β-catenin and GSK3β, which resulted in downregulation of the metastasis-associated proteins, the matrix metalloproteinases, MMP-2 and MMP-9, and COX-2. Here, PTGS2 is linked to hepatocellular carcinoma.