Menopause is characterized by the perturbation of the hypothalamic-pituitary-gonadal axis, including decreased estrogen levels, dysregulation of neurotransmitter such as serotonin, dopamine, and norepinephrine and an increase in the levels of the catabolic enzyme, monoamine oxidase A (MAO-A)—all of which have been implicated in depressive symptoms and vasomotor instability (Han et al., 2018). This evidence concerns the gene MAOA and menopause.