Similarly, in hepatocellular carcinoma, caudatin-induced inhibition of Wnt/β-catenin signaling suppressed COX-2 (Cyclooxygenase-2) and MMP-2/MMP-9 expressions to favor inhibited metastasis (Luo et al., 2013) (Table 1, Row 2). This evidence concerns the gene PTGS2 and hepatocellular carcinoma.