Its predictive value surpasses that of C-reactive protein (CRP), interleukin-6 (IL-6), and serum amyloid A. Additionally, the ratio of neutrophils to lymphocytes is closely linked to the severity of AP and the impairment of kidney function throughout the disease course, exhibiting high diagnostic efficiency for SAP-related AKI (34). The gene discussed is CRP; the disease is acute kidney injury.