This study focuses on three cytokines, interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α), owing to their controversial roles in peri-implantitis, with the aim of clarifying their diagnostic and prognostic utility in distinguishing healthy implants from diseased states [5,6]. The gene discussed is IL10; the disease is Peri-Implantitis.