Cytokine levels in PICF were markedly elevated in peri-implantitis cases: IL-6 (235.56 ± 56.34 pg/mL vs. 22.88 ± 8.06 pg/mL), IL-10 (73.13 ± 15.11 pg/mL vs. 13.13 ± 4.25 pg/mL), and TNF-α (148.94 ± 53.99 pg/mL vs. 8.31 ± 2.89 pg/mL). This evidence concerns the gene IL6 and Peri-Implantitis.