Most notably, cytokine levels were dramatically elevated in peri-implantitis cases: IL-6 showed a 10-fold increase (235.56 ± 56.34 pg/mL vs. 22.88 ± 8.06 pg/mL respectively in peri-implantitis and healthy group, d = 5.2), IL-10 levels were 5.5 times higher (73.13 ± 15.11 pg/mL vs. 13.13 ± 4.25 pg/mL respectively in peri-implantitis and healthy group, d = 5.4), and TNF-α demonstrated an 18-fold elevation (148.94 ± 53.99 pg/mL vs. 8.31 ± 2.89 pg/mL respectively in peri-implantitis and healthy group, d = 3.6). The gene discussed is TNF; the disease is Peri-Implantitis.