Immunohistochemically, the tumor cells were diffusely positive for CAM5.2, AE1/AE3, and ER; focally positive for CD10, EMA, vimentin, WT1, CDX2, and p16; and negative for PAX8, CK7, calretinin, GATA3, Napsin A, and TTF1. The gene discussed is PAX8; the disease is neoplasm.