An investigation of the roles of OGA and OGT in the inhibitory effects of kaempferol on protein O-GlcNAcylation and CRC revealed that inhibiting OGT weakened the ability of kaempferol to reduce protein O-GlcNAcylation (Figure 4G), whereas inhibiting OGA enhanced this effect (Supplementary Figure 3A). This evidence concerns the gene OGT and colorectal carcinoma.