In contrast, OGA inhibition and knockdown enhanced the anti-CRC effect of kaempferol, which we believe stems from the compensatory vulnerability state after OGA inhibition - TMG-induced O-GlcNAc over-accumulation leads to endoplasmic reticulum stress 34 and energy crisis 35, making cells more sensitive to OGT-targeted inhibition of kaempferol. The gene discussed is OGT; the disease is colorectal carcinoma.