OGT and neoplasm: It is worth noting that in the subcutaneous tumor model in mice, when the OGT-specific inhibitor OSMI-4 was used to inhibit O-GlcNAcylation modification, the antitumor effect of kaempferol not only did not show the expected synergistic effect but instead exhibited a significant antagonistic effect (combination therapy group vs monotherapy group, average tumor volume: 396.5588 mm3 vs 258.2066/172.4777/136.6953 mm3; Figure 4K).