Furthermore, we performed IHC staining of CLDN6, p-AMPK, and p-ULK1 in xenograft tumor tissues from MDA-MB-231/Vec+ADM and MDA-MB-231/CLDN6+ADM groups, and the results showed that p-AMPK and p-ULK1 were predominantly localized in the cytoplasm, and their expression was higher in MDA-MB-231/CLDN6+ADM group than that in MDA-MB-231/Vector+ADM group (Figure 5O). The gene discussed is ULK1; the disease is neoplasm.