Silencing GSDME in mice can attenuate AKI and inflammation.69 Autophagy induced GSDME-mediated pyroptosis is the major cause of cobalt chloride induced hypoxia-reoxygenation injury and AKI.70 In addition, GSDMD-mediated pyroptosis was widely activated in multiply types of kidney diseases including AKI, diabetic kidney disease, crystal-induced kidney disease and allograft injury in kidney transplantation.71,72 In our study, the GSDME-mediated pyroptosis but not GSDMD was activated in Lipin3 deficiency PTECs after cisplatin treatment. Here, GSDMD is linked to kidney disorder.