SQLE and neoplasm: β-glucan stimulation of hepatic macrophages induces squalene epoxidase (SQLE)-catalyzed formation of 24(S),25-epoxycholesterol (24(S),25-EC), which acts as a ligand for liver X receptors (LXRs) to activate LXR/RXR heterodimers and enhance transcription of anti-tumor genes (e.g., IFN-β, IFN-γ) 136.