In murine models of TI, heightened expression levels of spleen tyrosine kinase (SYK), lysine methyltransferase 5A (KMT5A), and CCHC-type zinc finger nucleic acid-binding protein (CNBP) are observed, using siRNA-mediated knockdown of KMT5A or CNBP to reduce the activity of SYK may slow down the development of atherosclerosis after MI 175. This evidence concerns the gene KMT5A and atherosclerosis.