Next, we found that in renal cancer cells, overexpression of MKRN2 (Fig. S3A and S3B) led to elevated β-Catenin phosphorylation and reduced β-Catenin protein expression, resulting in the attenuation of Wnt pathway that is marked by the down-regulation of signature genes (c-Myc, Cyclin D, Axin2, Bcl-2, MMP2, and MMP9) (Fig. 2D and Fig. S5A, S5B). Here, MMP2 is linked to renal carcinoma.