TUNEL fluorescence staining and flow cytometry suggested that MKRN2 overexpression (OE) increased apoptosis in renal cancer cells (Fig. 2E-2F and Fig. S4C-S4D), while significantly suppressing proliferative capacity (Fig. S3E-S3G), cell invasion and migration (Fig. S3I), and wound-healing capacity (Fig. S4A) in A498 and Caki-1 lines. Here, MKRN2 is linked to renal carcinoma.